Abstract

Pain and depression are intricately linked, with each capable of influencing the onset, progression, and management of the other. Chronic pain often leads to emotional distress, while depression can exacerbate the perception of pain. This article explores the biological, psychological, and social factors connecting pain and depression, delves into the mechanisms underlying their coexistence, and discusses therapeutic approaches. An emphasis is placed on multidisciplinary strategies to improve patient outcomes, highlighting the importance of addressing both conditions simultaneously for holistic care.