Abstract

Objective: To explore the clinical effect of predeposit, salvage and hemodilution autotransfusion on patients with Femoral Shaft Fractdure (FSF) surgery. Methods: Selected FSF patients were randomly divided into 3 groups: intraoperative blood salvage autotransfusion group, preoperative hemodilution autohemotransfusion group and predeposit autotransfusion. After the operation for 5 days, body temperature, heart rate, blood platelet (PLT) and Hemoglobin (Hb) of patients were determined; the concentrations of EPO and G-MSF in the 3 groups were calculated by ELISA assay; the content of CD14+ monocytes were calculated by FCM assay. The growth time and condition of the patient’s callus were determined at the 30^th, 45^th and 60^th days after operation. Cox regression analysis was used to analyze the correlation between EP0, G-MSF, CD14+ mononuclear content, callus growth and autotransfusion methods.

Results: There were no statistically significant differences in body temperature and heart rate between the 3 groups (P >0.05). PLT and Hb in Predeposit group were markedly increased compared to that in Salvage group and Hemodilution group. The concentrations of EPO and G-MSF in Predeposit group were markedly increased compared to that in Salvage group and Hemodilution group. The content of CD14+ monocytes in Predeposit group was significantly higher compared to that in Salvage group and Hemodilution group. Predeposit autotransfusion promotes callus growth more quickly. The concentration of EP0 and G-MSF were positively correlated with callus growth in the three groups, and the content of CD14+ monocytes was not correlated in any of the three groups.

Conclusion: Predeposit autotransfusion promoted the recovery of FSF patients after operation more quickly compared to salvage autotransfusion and hemodilution autotransfusion.

Keywords: Femoral Shaft Fractdure (FSF), Autotransfusion, Predeposit, Salvage, Hemodilution