Abstract

Exercise training is considered a foundation in the operation of type 2 diabetes, which is associated with impaired endothelial function. Still, the association of exercise training with endothelial function in type 2 diabetes cases has not been fully understood. This meta-analysis aimed to probe their associations with focus on exercise types. Exercise training, in particular aerobic and combined exercise, improves endothelial function in type 2 diabetes cases, but such an improvement appears to be weakened compared with non-diabetics. The endothelium, a monolayer of cells that provides a physical barricade between vessel lumen and vascular wall, is essential in maintaining vascular homeostasis, a process which is recognized to be primarily modulated via its release of a list of brokers that regulate blood coagulation and vascular tone. Endothelial dysfunction is appertained to the condition where the endothelium loses its physiological parcels but shows a tendency towards vasoconstriction, pro-thrombotic, and pro-inflammatory countries. In addition to being a well-recognized precursor of atherosclerosis, endothelial dysfunction has also been considered a pathophysiological hallmark characterized by type 2 diabetes.

Keywords: Exercise, Diabetic patients, Type 2 diabetes, Pathophysiological, Endothelium