Abstract

Immune-related neurological diseases, including multiple sclerosis (MS), systemic lupus erythematosus (SLE) with neurological involvement, and autoimmune encephalitis, are characterized by immune system dysregulation and inflammation within the central nervous system (CNS). Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNA regulation, play a crucial role in modulating gene expression and influencing immune cell function. This review examines the current understanding of epigenetic mechanisms in the pathogenesis of these diseases, highlighting their potential as therapeutic targets.