Journal of Alzheimers Disease & Parkinsonism
Open Access

Research Article

Epidemiology and Genetics of Alzheimer's Disease

Povova Jana^1*, Sery Omar², Tomaskova Hana¹, Vargova Lydia², Ambroz Petr¹, Luzny Jan¹, Pohlidalova Anna¹ and Janout Vladimir¹

¹Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Czech Republic

²Department of Biochemistry, Masaryk University Brno, Czech Republic

Corresponding Author:

Jana Povova
Department of Epidemiology and Public Health
Faculty of Medicine, University of Ostrava
Syllabova 19, Ostrava 3, Czech Republic
Tel: +420 733 784 093
E-mail: Jana.povova@osu.cz

Received date: December 20, 2014; Accepted date: January 20, 2015; Published date: February 03, 2015

Citation: Jana P, Omar S, Hana T, Lydia V, Petr A, et al. (2015) Epidemiology and Genetics of Alzheimer’s Disease. J Alzheimers Dis Parkinsonism 5:172. doi:10.4172/2161-0460.1000176

Copyright: © 2015 Jana P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Alzheimer’s disease (AD) is the most common form of dementia. It is a degenerative and incurable terminal disease. AD accounts for 75% of all forms of dementia all over the world. Its etiology is still unknown. Numerous risk factors of AD have already been discovered. In this paper, some preliminary results are presented. The results suggested that persons with AD often had cardiovascular disease in their history. Conversely, they did not have diabetes mellitus, hypertension and cerebrovascular disease. A relationship between the ApoE4 allele and a higher risk of AD was found (OR 2.52). Among ACE genotypes, the I allele increases the risk of AD, and in this pilot sample, the II genotype showed the OR on the borderline of significance (OR 1.43;95% CI 0.97-2.12).

Keywords