Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a challenging complication associated with antiresorptive and antiangiogenic medications. Traditional treatment approaches often involve extensive surgical interventions, which can be associated with significant morbidity. Recently, photobiomodulation (PBM) has emerged as a promising adjunct in MRONJ management, leveraging its anti-inflammatory, analgesic, and tissue regenerative properties. This review explores the synergistic use of PBM with minimal surgical interventions, highlighting its potential to promote healing while reducing treatment invasiveness. Clinical studies, biological mechanisms, and future perspectives on integrating PBM into MRONJ protocols are discussed.