ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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  • Research Article   
  • J Obes Weight Loss Ther 2022, Vol 12(3): 486
  • DOI: 10.4172/2165-7904.1000486

Efficacy of Intragastric Balloons for the Treatment of Obesity-a Systematic Review and Meta-analysis

Musthafa Chalikandy Peedikayil1*, Zenusha Edathodu2, Saud A Khan4, Reham Sindi3, Fahad Alsohaibani1 and Devol Edward Bentz5
1Deartpment of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
2The Queen's University of Belfast, Belfast, United Kingdom
3Clinical Nutritionist, Coventry University, United Kingdom
4Al Faisal University, Riyadh, Saudi Arabia
5Biostatistics and Epidemiology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
*Corresponding Author : Musthafa Chalikandy Peedikayil, Deartpment of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia, Email: musthafacpdr@gmail.com

Received Date: Mar 22, 2022 / Published Date: Apr 19, 2022

Abstract

Background: Intragstric balloons (IGB) are space-occupying devices that are inserted endoscopically into the stomach and removed after approximately 6 months for the treatment of obesity. IGBs are associated with short-term weight loss while having the advantage of preserving the normal anatomy of the stomach. The long-term efficacy of IGB on weight loss is still questioned. .

Objectives: To determine the short- and long-term efficacy of IGB for the treatment of obesity.

Methods: A systematic review and meta-analysis of the weight changes and BMI changes in patients who underwent an IGB procedure for obesity treatment was conducted. Articles that reported the mean and standard deviation of BMI and weight, and the number of patients before IGB insertion and at the time of IGB removal were selected. The shortterm outcomes were assessed from the IGB insertion to its removal. The Long-term outcomes were assessed from six months and beyond from removal of the IGB. The comprehensive literature search was performed using search engines, PubMed, and other sources. The methodological index for non-randomized studies (MINORS) was used to assess the methodological quality of the studies. Guidelines and protocols as per the "PRISMA guidelines" were adhered to during the systematic review and meta-analysis.

Results: A total of 27 articles were reviewed for the systematic review. The total number of patients at the time of IGB insertion was 4400. The short-term treatment effect of the IGB on obesity was assessed by meta-analysis of 15 articles. The observed standardized mean differences ranged from 0.2949 to 1.5596, with most estimates being positive (100%). The estimated average standardized mean difference based on the random-effects model was 0.7540 (95% CI: 0.5546 to 0.9535). Therefore, the average outcome differed significantly from zero (z = 7.4106, p < 0.0001).

A total of six studies were included in the analysis to assess the long-term effect of IGB treatment on obesity. The observed standardized mean differences ranged from -0.3239 to 0.0000, with most estimates being negative (83%). The estimated average standardized mean difference based on the random-effects model was -0.0961 (95% CI: -0.2113 to 0.0190). Therefore, the average outcome did not differ significantly from zero (z = -1.6364, p = 0.1018).

Conclusion: Intragastric balloons are effective in the treatment of obesity in the short-term. The meta-analysis did not show a beneficial effect on the treatment of obesity after removal.

Keywords: Obesity; Intra-gastric balloon; Bio-enteric intra-gastric balloon; Gastric balloon

Citation: Peedikayil MC, Edathodu Z, Khan SA, Sindi R, Sohaibani FIA, et al. (2022) Efficacy of Intragastric Balloons for the Treatment of Obesity-a Systematic Review and Meta-analysis. J Obes Weight Loss Ther 12: 481. Doi: 10.4172/2165-7904.1000486

Copyright: © 2022 Peedikayil MC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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