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Hindi Special Issue Article
Efficacy of Artesunate Plus Amodiaquine for Treatment of Uncomplicated Clinical Falciparum Malaria in Severely Malnourished Children Aged 6?59 Months, Democratic Republic of Congo
P. Mitangala Ndeba1*, U. D’Alessandro2, P. Hennart3,5, P. Donnen3,5, D. Porignon4, G. Bisimwa Balaluka5,6, A. Bisimwa Nkemba6, N Cobohwa Mbiribindi6 and M. Dramaix Wilmet1,51Centre de recherche: épidémiologie, Biostatistique et recherche clinique, Ecole de Santé Publique, Université Libre de Bruxelles (Belgique)
2Department of Parasitology, Institute Tropical Medicine, Antwerp, Belgium
3Centre de recherche : épidémiologie et médecine préventive, Ecole de santé Publique, Université Libre de Bruxelles (Belgique)
4Unité de santé internationale, Département des Sciences de la Santé Publique, Université de Liège (Belgique).
5Centre Scientifique et Médical de l’Université Libre de Bruxelles pour ses Activités de Coopération (CEMUBAC)
6Département de nutrition, Centre de Recherche en Sciences Naturelles / Lwiro (République Démocratique du Congo)
- *Corresponding Author:
- Mitangala Ndeba Prudence
Centre de recherche: épidémiologie, biostatistique et recherche clinique
Ecole de Santé Publique, Université Libre de Bruxelles
CP 598, Route de Lennik 808, 1070 Bruxelles
Tel: +243 998 088 072
E-mail: prudendeb@yahoo.fr
Received Date: January 01, 2012; Accepted Date: April 21, 2012; Published Date: April 23, 2012
Citation: Ndeba PM, D’Alessandro U, Hennart P, Donnen P, Porignon D, et al. (2012) Efficacy of Artesunate Plus Amodiaquine for Treatment of Uncomplicated Clinical Falciparum Malaria in Severely Malnourished Children Aged 6–59 Months, Democratic Republic of Congo. J Clin Exp Pathol S3:005. doi: 10.4172/2161-0681.S3-005
Copyright: © 2012 Ndeba PM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Abstract
Background: Recent published studies on efficacy and safety of antimalarial treatment in children with Severe
Acute Malnutrition (SAM) suffering from uncomplicated malaria are not available.
Methods: Between March 2007 and December 2010 the efficacy of AS+AQ in treating uncomplicated malaria
children under five with SAM was carried out in Lwiro (Eastern Republic Democratic of Congo) according to the WHO
standard protocol. Among the 445 children included, 69 had SAM. AS+AQ was given according to national protocol.
Analysis was done using per protocol method. Odds ratio (OR) and their 95% confidence interval (95% CI) were
computed.
Results: The treatment failure rate was 24.4% of 414 infections included in the analysis. After adjustment for
malaria parasitemia, ACPR in children without SAM were 73.0% when it was 91.4% among those with SAM (OR
3.15 95%CI 1.19 – 8.30). Malaria parasitemia median at admission was statistically low among children who had
subsequently Adequate Clinical and Parasitological Response (ACPR).
Conclusion: AS+AQ has a good efficacy among children with both uncomplicated falciparum malaria and
malnutrition including severe acute form. AS+AQ dosing national strategy unmodified can be used, to treat under five
children with malnutrition including severe acute form suffering from uncomplicated malaria.
