ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

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Efficacy and Safety of Huanglian Wendan Decoction Combined with Donepezil in Patients with Mile Alzheimer’s disease: A Randomized Controlled Trial

Lin Lin1*, Yang QiHan1,2,3, Li TingTing2, Hou JiXin4, Hou JiXin, Duan Ran4 and Wen Quan5
1Department of Elderly Health/collaborative innovation center of elderly care and health, Chengdu Medical College, Chengdu, China
2Department of Nursing, Chengdu Medical College, Chengdu, China
3Department of Cardiovascular Medicine, Mianyang Traditional Chinese Medicine Hospital, Mianyang, China
4Department of Cardiovascular Medicine, Chengdu Medical College, Chengdu, China
5Department of Traditional Chinese Medicine, Chengdu Eighth People’s Hospital, Chengdu, China
*Corresponding Author: Lin Lin, Department of Elderly Health/collaborative innovation center of elderly care and health, Chengdu Medical College, Chengdu, China, Tel: +86 13688119536, Email: 16linlin@163.com

Received Date: Oct 12, 2022 / Published Date: Nov 11, 2022

Citation: Lin L, QiHan Y, TingTing L, JiXin H, Ran D, et al. (2022) Efficacy and Safety of Huanglian Wendan Decoction Combined with Donepezil in Patients with Mile Alzheimer’s disease: A Randomized Controlled Trial. J Alzheimers Dis Parkinsonism 12: 554.DOI: 10.4172/2161-0460.1000554

Copyright: © 2022 Lin L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background and Objective: Currently, drugs for Alzheimer's disease (AD) are unable to slow or prevent neuronal damage. Clinical studies have shown that a Traditional Chinese Medicine (TCM) decoction combined with conventional Western medicine has a synergistic effect in the treatment of AD. This study aimed to investigate the clinical efficacy and safety of the Huanglian Wendan Decoction (HLWD) combined with donepezil in patients with AD.

Methods: Fifty-two eligible patients were randomly and equally assigned into two groups: one receiving HLWD and donepezil and one control group receiving donepezil alone for 12 weeks. The primary endpoints were measured by the Mini-Mental State Examination (MMSE) and serum levels of Interleukin-1β (IL-1β) and Interleukin-6 (IL-6). Secondary outcomes were evaluated using the Wechsler Memory Scale (WMS), the activity of daily living (Barthel index), and the TCM Symptom Grading Quantitative Scale Score (TCMS).

Results: After 12 weeks of treatment, the MMSE, WMS, and Barthel index scores in the patients of both the groups were higher than those before treatment (P<0.05). TCMS was lower than before treatment in both the groups (P<0.05), whereas the MMSE, WMS, and Barthel index scores of the HLWD group were significantly higher than those of the control group (P<0.05). After treatment, the TCMS score of the HLWD group was significantly lower than that of the control group (P<0.05). Additionally, IL-1β and IL-6 levels in both the groups decreased (P<0.05), while they were significantly lower in the HLWD group than those in the control group (P<0. 05).

Conclusion: HLWD combined with donepezil has significant clinical efficacy in the treatment of patients with mild AD, improving their cognition, memory function, self-care ability, TCM symptoms, and reducing the levels of IL-1β and IL-6.

Keywords

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