Abstract

In the present study, power ultrasound (US) using the antisolvent sonocrystallization technique (ASC) was used to improve the physicochemical properties of Irbesartan which a poorly water-soluble drug. The powders produced were characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectrophotometry (FTIR) and X-ray Diffraction (XRD). The effect of process variables on particle size, solubility and dissolution were studied. Flowability, compressibility and mechanical properties of the produced powders were also assessed. Using ASC led to considerable decrease in the particle size. SEM studies showed that the ASC produced particles were almost spherical with regular size. Thermal behavior, XRD patterns and FT-IR spectra of raw Irbesartan and powders obtained by ASC have shown no significant differences.

Keywords: Ultrasound; Spectrophotometry; Particle size; Sonocrystallization