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Hindi Effect of Stromal Cell and Bone Marrow Stem Cell Fusion in Patients with Mild Alzheimerâs Disease: A Proof of Concept Study
*Corresponding Author: Himanshu Bansal, Mother Cell Spinal Injury and Stem Cell Research, Anupam Hospital, Uttrakahand, India, Tel: +919634501234, Email: drbansalh2019@gmail.comReceived Date: Aug 06, 2019 / Accepted Date: Nov 30, 2019 / Published Date: Dec 07, 2019
Citation: Bansal H, Meonah SST, Agarwal A, Leon J, Preoteasa L, et al. (2019) Effect of Stromal Cell and Bone Marrow Stem Cell Fusion in Patients with Mild Alzheimer’s Disease: A Proof of Concept Study. J Alzheimers Dis Parkinsonism 9: 481.
Copyright: © 2019 Bansal H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Objective: This article presents a proof of concept study on the efficacy of autologous treatment with adipose tissue stromal cells and bone marrow stem cells on patients with mild Alzheimer’s disease.
Methods: Eligible patients were selected on the basis of SPECT test, NINCDS-ADRDA criteria and specific inclusion and exclusion criteria. Cognitive status of the patients was assessed before and after autologous intrathecal administration of stem cells through different assessment tests. Neurological status was determined using PET scan, SPECT imaging and CSF protein analysis.
Results: Steady improvement in the cognitive capability of patients was observed in the first six months of treatment. Later, there was a decline in the neurological ability which was revealed in the cognitive assessments. PET scan results were not changed.
Conclusion: In mild AD patients, the effect was obvious although short lived. The enhancement of the general status of the patients revealed the therapeutic potential of the therapy. Future large-scale clinical trials with more study subjects to determine the safety and efficacy of the therapy in different clinical settings are warranted.
