Effect of RBD Mutation (Y453F) in Spike Glycoprotein of SARS-CoV-2 on Neutralizing Antibody Affinity
Received Date: Jan 18, 2021 / Accepted Date: Feb 01, 2021 / Published Date: Feb 08, 2021
Abstract
Background: Infection with Receptor-Binding Domain (RBD) mutant (Y453F) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from farmed minks is known to widely spread among humans.
Methods: We investigated the characteristics of SARS-CoV-2 RBD Y453F mutant using three-dimensional structural analysis. We investigated the effect of the RBD Y453F mutant of SARS-CoV-2 on neutralizing antibodies in serum derived from Coronavirus Disease 2019 (COVID-19) positive patients.
Results: Our studies suggest that virus variants with RBD Y453F mutation partially escaped detection by four neutralizing monoclonal antibodies and neutralizing antibodies in serum.
Conclusion: Consequently, raising concern that infection of SARS-CoV-2 mutants that cause serious symptoms in humans may spread globally.
Keywords: RBD Y453F mutant; Neutralizing antibody; SARS-CoV-2; COVID-19
Citation: Hayashi T, Yaegashi N, Konishi I (2021) Effect of RBD Mutation (Y453F) in Spike Glycoprotein of SARS-CoV-2 on Neutralizing Antibody Affinity. Diagnos Pathol Open 6: 181. Doi: 10.4172/2476-2024.1000181
Copyright: © 2021 Hayashi T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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