Abstract

Due to its mechanical adaptability, processability, and minimal immunogenic reaction, silk biomaterials are frequently employed in tissue engineering applications. However, additional alterations are frequently needed to improve silk biomaterials for a particular biological application since they lack cell binding sites. A variety of bioactive compounds may be covalently attached to silk surfaces using the surface modification technique plasma immersion ion implantation in order to produce desired biological effects. However, nothing is known about how PIII treatment would affect the surface and bulk characteristics of silk biomaterials. In order to explore PIII-treated silk biomaterials as a platform for biological applications, this study's goal is to do so. The surface and mass of silk films were studied with and without PIII treatment. Features, such as the in vivo immunological response, mechanical, chemical, and degrading properties. The insertion of oxygen and nitrogen functional groups as well as the densification of the silk’s surface layer was seen to change the surface chemistry of silk after PIII treatment.