Abstract

Oxidative stress plays a vital role in human diseases. GABA tea and mulberry leaves show antioxidant effects and scavenge free radicals. The mulberry leaf-GABA tea (ML-GABA tea) product has the effect of reducing body fat. Therefore, this study evaluates the effect of ML-GABA tea on antioxidant activity and obese-related gene expression. We analyzed 27 subjects, including 18 female and 9 men subjects. The results showed that malondialdehyde (MDA) in plasma and erythrocyte catalase enzyme activity decreased significantly (p <0.05) after the subjects consumed MLGABA tea for 6 weeks. There was no significant difference (p> 0.05) in the enzyme activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR). Additionally, we found no significant change (p> 0.05) of adiponectin, leptin, IL-6, and visfatin gene expressions in the obese group after consuming ML-GABA tea for 6 weeks. In summary, our findings indicate that ML-GABA tea inhibits MDA formation in the body, reducing the activity of catalytic enzymes. ML-GABA tea is a healthy food that inhibits the formation of body fat and has antioxidant effects.

Keywords: Mulberry; GABA; Obesity; Malondialdehyde; Antioxidative