Abstract

Breast cancer remains a significant health concern globally, with nodal involvement being a crucial prognostic factor. The role of adjuvant treatment in patients with N1 stage breast cancer and its impact on the outcomes of regional nodal irradiation (RNI) has been a subject of debate. This research article aims to review the current evidence regarding the effect of adjuvant treatment on the results of RNI in N1 breast cancer patients. We conducted a comprehensive literature search to identify relevant studies, focusing on clinical trials, retrospective analyses, and systematic reviews. Our findings suggest that adjuvant treatments such as chemotherapy, endocrine therapy, and targeted therapy can influence the efficacy and toxicity profile of RNI in N1 breast cancer patients. Understanding these effects is crucial for optimizing treatment strategies and improving patient outcomes. Further research is warranted to elucidate the specific interactions between adjuvant treatments and RNI in this patient population.