Abstract

Tropical diseases pose significant challenges to global public health, particularly in regions with limited resources and inadequate healthcare infrastructure. The development of effective drugs against these diseases is crucial for mitigating their impact and improving the well-being of affected populations. Drug discovery efforts for tropical diseases have seen notable progress in recent years, driven by advances in scientific understanding, technological innovation, and collaborative research initiatives. Target-based drug discovery approaches, focusing on identifying specific molecular targets within pathogens, have gained traction, leading to the discovery of novel drug candidates with potential efficacy against diseases such as malaria, dengue fever, leishmaniasis, and Chagas disease. This abstract provides an overview of recent advancements in drug discovery for tropical diseases, highlighting key strategies, challenges, and opportunities in this field.