Abstract

Objective: The primary objective focuses on amount of blood loss from cesarean section in low-risk uterine atony patients in the carbetocin group comparing to that in the oxytocin group. The secondary objectives are to compare the incidences of postpartum haemorrhage (PPH) and blood transfusion, additional uterotonic use, hemoglobin and hematocrit change within 24 h after cesarean section and side effects between each group. Materials and methods: There were 122 pregnant women eligible in this non-inferior double-blind randomized controlled study comparing two uterotonic drugs (carbetocin and oxytocin) used in cesarean section at department of obstetrics and gynecology, faculty of medicine vajira hospital, navamindharathiraj university from July 2016 to January 2017. The data including amount of blood loss, incidences of PPH and blood transfusion, additional uterotonic use, hemoglobin and hematocrit change in 24 h after cesarean section and side effects were collected. Results: There were 61 pregnant women in each group. Amounts of blood loss in carbetocin group at immediate post opération and 24 h after operation were less than those in oxytocin group, but there was no statistical significance (P=0.097 and 0.1, respectively). In oxytocin group, there was significantly greater additional uterotonic use, but there was no statistic difference in incidences of PPH and blood transfusion, hemoglobin and hematocrit change within 24 h after cesarean section and side effects in both groups. Conclusion: Blood loss in low-risk uterine atony cesarean section in carbetocin was not different from oxytocin. Although additional uterotonic use was significantly lower in carbetocin group, incidences of PPH and blood transfusion, hemoglobin and hematocrit change within 24 h after cesarean section and side effects in both groups were not different.

Keywords: Carbetocin; Oxytocin; Cesarean section; Postpartum hemorrhage