Abstract

Gut-innervating nociceptor sensory neurons reply to noxious stimuli with the aid of initiating protecting responses which includes ache and inflammation; however, their position in enteric infections is unclear. Here, we locate that nociceptor neurons seriously mediate host protection in opposition to the bacterial pathogen Salmonella enterica serovar Typhimurium (STm). Dorsal root ganglia nociceptors shield towards STm colonization, invasion, and dissemination from the gut. Nociceptors modify the density of microfold (M) cell in ileum Peyer’s patch (PP) follicleassociated epithelia (FAE) to restrict entry factors for STm invasion. Downstream of M cells, nociceptors preserve tiers of segmentous filamentous microorganism (SFB), a intestine microbe living on ileum villi and PP FAE that mediates resistance to STm infection.