Abstract

Donor-derived infections (DDIs) are a significant concern in organ transplantation. The prevention, detection, and management of DDIs are essential for transplant success. This review presents the latest best practices and guidelines developed by the AST Infectious Diseases Community of Practice. To summarize the guidelines and recommendations for managing donor-derived infections in organ transplantation, with a focus on best practices for minimizing risks and optimizing outcomes. Literature review of existing guidelines, clinical studies, and expert opinion regarding DDIs in organ transplantation. The guidelines were developed using evidence-based approaches from recent cases, surveillance systems, and peer-reviewed data. Best practices were identified in areas such as pretransplant screening, perioperative management, and post-transplant monitoring. Key pathogens, including viruses, bacteria, fungi, and parasites, were addressed with recommended preventive and therapeutic strategies. Effective DDI management requires a multidisciplinary approach. The AST guidelines provide a comprehensive framework to mitigate DDI risks while ensuring patient safety and optimizing long-term outcomes in organ transplantation.