Abstract

In the realm of biomaterials, the nucleus, once overlooked, is now emerging as a focal point of exploration and innovation. This abstract delves into the evolving understanding of the nucleus within biomaterials research, highlighting its pivotal role in cellular function, gene expression, and biological responses to biomaterials. Recent advancements have unveiled the nucleus as a dynamic organelle that orchestrates intricate signalling pathways and molecular interactions crucial for tissue regeneration, immune response modulation, and therapeutic efficacy of biomaterial implants. By examining the interplay between biomaterial properties and nuclear dynamics, researchers are uncovering novel insights into cellular mechanotransduction, epigenetic modifications, and nuclear envelope interactions that influence cellular fate and tissue integration. This abstract explores how manipulating nuclear interactions with biomaterials through substrate stiffness, topography, and biochemical cues can modulate gene expression patterns and enhance desired cellular outcomes. Moreover, the abstract discusses the implications of nuclear-centric biomaterial designs in advancing personalized medicine, regenerative therapies, and tissue engineering applications. By harnessing the regulatory potential of the nucleus, biomaterial strategies can be tailored to optimize therapeutic outcomes, mitigate immune responses, and promote tissue-specific regeneration in diverse clinical settings. In conclusion, the nucleus is emerging as a central protagonist in the realm of biomaterials, offering a deeper understanding of cellular mechanisms and unlocking new avenues for innovation in biomedical research and clinical practice. Future endeavors in biomaterial design and application will continue to explore and leverage the nucleus as a key determinant of cellular behavior and therapeutic efficacy, shaping the future landscape of biomaterial-driven healthcare solutions.