Abstract

Acute kidney injury (AKI) is a severe condition characterized by a sudden loss of kidney function, necessitating innovative treatment approaches. Traditional Chinese Medicine (TCM) compounds have gained attention for their potential therapeutic benefits in AKI. This article explores the discovery of new mechanisms by which TCM compounds exert their effects in AKI treatment. TCM compounds have demonstrated anti-inflammatory properties, inhibiting inflammatory pathways and reducing kidney inflammation. Additionally, they possess antioxidant properties that counteract oxidative stress-induced kidney damage. TCM compounds also modulate immune responses, regulating immune cell activation and reducing pro-inflammatory cytokine release. Promising TCM compounds, such as Astragalus membranaceus and Rheum palmatum, have shown renoprotective effects in animal models. Integrating TCM with conventional medicine could enhance patient care and treatment outcomes. However, further research and clinical trials are necessary to validate the safety, efficacy, and optimal administration of TCM compounds in AKI treatment. The exploration of TCM compounds in AKI represents a convergence of ancient wisdom and modern scientific inquiry, offering the potential for personalized and holistic care in AKI management.