Abstract

Although the in vitro analysis of cultured cell lines is associated with arti-facts related to effects attributed to a non-physiological environment and long-term passage in culture, it was shown that cancer cell lines retain most of the genomic features of the primary tumour. This has not yet been shown for proteomic features of cancer cell lines.

Keywords: Apoptosis; Drug testing; Drug sensitivity; Tumour environment; Xenograft; Pharmacological interventions