Differences in Acetic Acid Ototoxicity in Guinea Pigs are Dependent on Maturity
*Corresponding Author
:
Takafumi Yamano, Section of Otorhinolaryngology, Department of Medicine, Fukuoka Dental College, Japan, Tel: 81-92-801-0411, Fax: 81-92-801-3678, Email: yamano@college.fdcnet.ac.jp
Abstract
Objectives: The objective was to study if the difference exist in drug ototoxicity between less mature and mature guinea pigs.
Methods: The matured animal group had a body weight of 400 g and the less mature animal group had a body weight of 200 g. After compound action potential of the eight cranial nerves was measured, the middle ear cavity was filled with acetic acid.
Results: The less mature animal group was more sensitive to the acetic acid treatment than the more mature animal group.
Conclusion: We suggest that a difference in ototoxicity of certain otic drop treatments may exist between pediatric and adult patients.
Keywords: Ototoxicity, Acetic acid, maturity, Guinea pig
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