Abstract

Background and Objectives: DM and periodontitis are two chronic and customary diseases with close relationship together affecting public health and quality of life. The aim of this study was to research the effect of resveratrol supplementation in adjunct with non-surgical periodontal treatment (NST) on blood sugar , triglyceride, periodontal status and inflammatory markers in type 2 diabetic patients with periodontitis .

Materials and Methods: This double-blind clinical test study was conducted on 43 diabetic patients with periodontitis mentioned the Endocrinology Clinic at Golestan Hospital in Ahvaz, Iran. All subjects were randomly assigned into two groups of intervention and control. The intervention and control groups received either 480 mg/d resveratrol or placebo capsules (2 PCs) for four weeks. All subjects underwent non-surgical periodontal therapy during the intervention period. Anthropometric parameters, 24-hour dietary recall, fasting blood glucose , insulin, insulin resistance (HOMA-IR), triglycerides, pocket depth (PD), IL6 and TNFα were evaluated altogether subjects pre- and post-intervention.

Results: The mean serum levels of fasting insulin and insulin resistance (HOMA-IR) were significantly (P=0.02, P=0.045, respectively) lower within the intervention group compared with the control group (10.42 ± 0.28 and 10.92 ± 0.9; 3.66 ± 0.97 and 4.49 ± 1.56, respectively ). Moreover, significant difference (P < 0.001) was obtained within the mean pocket depth (PD) between the intervention and control groups (2.35 ± 0.6 and 3.38 ± 0.5, respectively) post-intervention. within the intervention group, the mean serum level of IL6 was reduced significantly (P= 0.039) post-intervention (1.58 ± 1.06 and 2.19± 1.09). No significant differences were seen in the mean levels of fasting blood glucose, triglycerides, IL6 and TNFα between the 2 groups post-intervention.

Conclusions: it's suggested that resveratrol could also be recommended as adjuvant therapy along side non-surgical periodontal treatment in diabetic patients with periodontitis.

Keywords: Type 2 DM , periodontitis , Resveratrol, Insulin resistance, Inflammatory markers