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Hindi Research Article
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD FOR THE SIMULTANEOUS DETERMINATION OF TAMSULOSIN AND DUTASTERIDE IN BULK DRUGS AND PHARMACEUTICAL DOSAGE FORMS USING UV SPECTROPHOTOMETRIC METHOD
Abstract
A new simple, precise method for simultaneous estimation of Tamsulosin and Dutasteride using UV spectroscopy has been developed. The present method involves the solving of simultaneous equations (Vierodt's method) for UV spectroscopy. Tamsulosin and Dutasteride were found to have absorbance maxima at 226nm and 206 nm respectively in methanol Both these drugs obeyed Beer's law in the concentration range of 1âÃâ¬ÃÂ30 μg/ ml. The high values of correlation coefficients (r2) indicated good linearity of Calibration curve for both the drugs. The linearity curved showed %RSD NMT 2. The recoveries of Tamsulosin and Dutasteride from the standard mixture solution were found to be 100.1% and 99.50 % respectively. Forced degradation was also performed using 0.1N HCl,).1N NaOH, thermal degradation, light and oxidation with 1 – 3% H2O2 .it was found. Only small amount of drug got degraded which was within the limits. The method developed is simple and precise showing 100.1% and 108.1% purity for Tamsulosin and Dutasteride respectively and all other validation parameters were found to be within limits %RSD NMT 2. Hence the method developed can be used for routine lab analysis.
