Determination of the Cell Orientation Pathway and Receptor Complex Signals
Received Date: Apr 10, 2023 / Accepted Date: May 03, 2023 / Published Date: May 08, 2023
Abstract
Vertebrate proteins activate several distinct pathways. Intrinsic differences among ligands and Frizzled receptors, and the availability of pathway-specific co receptors. A secreted glycoprotein, Cthrc1, is involved in selective activation of the planar cell polarity pathway by proteins. Cell-surface-anchored Cthrc1 bound to proteins, Frizzled proteins, and Ror2 and enhanced the interaction of proteins and Frizzled /Ror2 by forming the Cthrc1 - Frizzled /Ror2 complex. These results suggest that Cthrc1 is a Frizzled cofactor protein that selectively activates the Frizzled /PCP pathway by stabilizing ligand-receptor interaction.
Citation: Pitters H (2023) Determination of the Cell Orientation Pathway and Receptor Complex Signals. J Biochem Cell Biol, 6: 186.
Copyright: © 2023 Pitters H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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