Abstract

Metabolic disorders, encompassing obesity, Type-2 diabetes, and metabolic syndrome, pose significant global health challenges. Cytokines, key signaling molecules primarily associated with immune response regulation, also play crucial roles in the pathophysiology of these disorders. This review explores the mechanisms through which cytokines such as TNF-α, IL-6, and IL-1β contribute to metabolic dysregulation, including insulin resistance and inflammation. Understanding these pathways provides insights into potential therapeutic strategies, including anticytokine therapies and lifestyle interventions, aimed at mitigating metabolic disorders and improving public health outcomes