Abstract

Discoid Lupus Erythematosus (DLE) is the most common subtype of Cutaneous Lupus Erythematosus (CLE). There are two types of Discoid LE Hypertrophic and Atrophic type. Malignant transformation of Discoid LE is few and far between.

The first case study is a 35-year-old female, known case of Systemic Lupus Erythematosus (SLE) with seizure and polyarthritis presented with an ulcer over the lip for 8 months. Edge wedge biopsy of the lesion was done, and a diagnosis of hypertrophic lupus erythematosus was rendered. The second case report is about A 50-year-old female with a hypopigmented patch measuring 8 × 4 cm present with a raised warty like lesion with black discoloration measuring 3 × 3 cm present over the patch over the right shoulder. Punch biopsy was diagnosed as Discoid lupus erythematosus. Microscopy of wide local excision however turned out to be squamous cell carcinoma in a background of DLE in both the patients.

We report two cases of Lupus Erythematosus which is associated with squamous cell carcinoma in the same lesion and the need of careful diligence whilst reporting the diagnosis.

Keywords: Squamous cell carcinoma; Discoid lupus erythematosus; Pseudoepitheliomatous hyperplasia