Abstract

This mini-review regroups the distinct cutaneous lesions observed in the context of humoral immunity. The specific cutaneous immune responses can be divided in two main groups of diseases: A first group that is in relation with the production of circulating immune complexes and a second group corresponding to the auto-immune diseases that are provoked by the production of autoantibodies directed against specific proper molecules of the patients. Histologically, the first group is dominated by lesions of cutaneous leukocytoclastic vasculitis. The second group is dominated by the Autoimmune Bullous Dermatoses. Nevertheless, there are bridges between the 2 groups of diseases. Both can affect the same patient and provoke distinct lesions in a single skin sample.

Keywords: Humoral immunity; Auto immune disease; Leukocytoclasic vasculitis; Urticarial; Levers faciale granuloma; Erythema elevatum diutinum; Autoimmune Bullous Dermatosis (AIBD); Pemphigoid; Epidermolysa bullous acquisita; Pemphigus; Linear IgA dermatosis; Herpetiform dermatitis