Abstract

The clinical management of Endometrial Cancer (EC) in the UK is undergoing significant changes with the incorporation of new guidelines and targeted therapies. The KNOW-EC (Knowledge of Endometrial Cancer) survey, conducted via telephone interviews with 63 Healthcare Professionals (HCPs) in late 2021, aimed to capture current and anticipated real-world practices in EC care. The survey, which aligned with British Gynaecological Cancer Society and European Society for Medical Oncology recommendations, revealed considerable variations in diagnostic and treatment practices. While 89.7% of respondents reported using somatic Mismatch Repair (MMR) deficiency testing routinely, only 9.8% had access to polymerase epsilon (POLE) sequencing. Key barriers to the swift adoption of new therapies included funding, limited staff, and insufficient resources. The survey also emphasized the need for improved access to comprehensive biomarker testing and greater educational support for HCPs. These findings underscore the necessity for standardized practices and enhanced resources to optimize EC management across the UK.

Keywords: : KNOW-EC; Endometrial cancer; Barriers; Patients; Society