Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Covid-19 Infection: The Perspectives on Age-Dependent Difference in Immune Responses and Immunological Strategies to Reduce Viral Burden

*Corresponding Author:

Copyright: © 2020  . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 
To read the full article Peer-reviewed Article PDF image

Abstract

Covid-19 is caused by the novel strain of Corona virus named as SARS-CoV-2 because of its homology with
SARS infection and it is first detailed in Wuhan, China in December 2019. From that point forward, it has spread
globally, already contaminating a large number of individuals worldwide and has been proclaimed as a pandemic by
the WHO (World Health Organization) on March 2020. SARS-CoV-2 causes acute respiratory infection with
fluctuating seriousness in various age groups, wherein geriatric patents in general will have serious disease. In
children it is moderately spread till-date. A few contrasts in the pathogenesis of Covid-19 among pediatric and
geriatric patients have been proposed to clarify these differences. Severe Covid-19 disease is associated with high
and persistent viral burdens in the elderly patients. Children have strong innate immune response because of
trained immunity (secondary to live-vaccines and frequent viral infections), leading to presumably early control of
infection at the site of entry and also the risk factors associated with children were very less as compared to elderly
individuals. The expression of primary target receptor for SARS-CoV-2, i.e. angiotensin converting enzyme-2
(ACE-2), decreases with age which has lung defensive effects and the severity of the disease can be explained by
the presence of enzyme called Furin. Henceforth, this review will highlight the clinical features, disease
pathogenesis, age-dependent difference in immune responses and immunological strategies to reduce viral burden.

Keywords

Top