Journal of Biotechnology & Biomaterials
Open Access

Review Article

Coupling Analytical Methods for Detection of Microparticles: The Possibilities for Improvement

Internal Medicine Department, State Medical University of Zaporozhye, 26, Mayakovsky Avenue, Zaporozhye, Ukraine

*Corresponding Author:

Berezin AE
Internal Medicine Department
State Medical University of Zaporozhye
26, Mayakovsky Avenue, Zaporozhye, Ukraine
Tel: +380612894585
E-mail: dr_berezin@mail.ru

Received date: April 05, 2017; Accepted date: May 15, 2017; Published date: May 22, 2017

Citation: Berezin AE (2017) Coupling Analytical Methods for Detection of Microparticles: The Possibilities for Improvement. J Biotechnol Biomater 7:257. doi:10.4172/2155-952X.1000257

Copyright: © 2017 Berezin AE. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Microparticles (MPs) are considered important diagnostic biological markers in many diseases with promising predictive value. There are several methods that currently used for the detection of number and characterization of structure and features of MPs. Therefore, the MP detection methods have been remained pretty costly and time consuming. The review is depicted the perspectives to use coupling methods for MP measurement and structure assay. Indeed, there is large body evidence regarding that the combination of atomic force microscopy or coupling nanoparticle tracking analysis (NTA) with microbeads, plasmon resonance method and fluorescence quantum dots could exhibit much more accurate ability to detect both number and structure of MPs when compared with traditional flow cytometry and fluorescent microscopy. Whether several combined methods would be useful for advanced MP detection is not fully clear, while it is extremely promising.

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