Abstract

Introduction: Thyroid and prolactin hormone levels are associated with fertility disorders among women. This study aims to find out the correlation between hyperprolactinemia and its correlates with hypothyroidism in female infertility.

Methodology: We conducted a cross-sectional study on 200 women who were experiencing from the condition of infertility and was referred to the department of biochemistry at Dr. Essa’s laboratory institute at Karachi, Pakistan. The patients were enrolled for a period of 5 years, which is from 2011 to 2015. The inclusion criteria was cases with a diagnosis of primary infertility with over one year duration of marriage. Legitimate written informed consent was performed on patient recruitment. Moreover the collected data was interpreted by using SPSS version 20.0.

Results: The total of 200 recruited cases gathered in the study to evaluate the fertility status. Comparing the TSH value with the fertility status of the women the TSH hormone levels were abnormal in 36(100) of our patients who were infertile with none of the abnormal TSH hormone levels found in fertile women with a p-value of <0.001. The prolactin hormone levels similarly showed 79(89) of the patients having abnormal prolactin hormone level who were infertile while 103(86) patients have normal prolactin hormone levels and they were fertile with a p-value of <0.001.

Conclusion: There were a higher percentage of patients with abnormal prolactin levels who were infertile compared to abnormal thyroid levels. In conclusion estimation of prolactin and TSH levels might be considered essential in assessment of patient with fertility disorders.

Keywords: Thyroid; Prolactin; Fertility disorders; Thyroid stimulating hormone