Comparison of Mean Level of Hemoglobin A1C Between β-thalassemia Traits and Normal Non- Diabetic Individuals
Received Date: Jan 25, 2022 / Published Date: Feb 22, 2022
Abstract
Objective: To compare the mean level of hemoglobin A1C between β-thalassemia traits and normal non-diabetic individuals.
Study design: Case-control study.
Place and duration of the study: Department of pathology, PAEC general hospital H/11-4 Islamabad for a duration of 6 months from January 2021 to June 2021.
Methodology: Complete blood count by light scatter principle and hemoglobin A1C by High-Performance Liquid Chromatography (HPLC) of fifty normal (controls) and fifty known β-thalassemia traits (cases) were determined. Data were analyzed using SPSS version 16.
Results: A total of 50 known β-thalassemia traits and normal non-diabetic individuals were included in the study as cases and controls respectively. Cases and controls were age-gender matched. The mean hemoglobin level of cases i.e known β-thalassemia traits was 11.37+1.56 g/dl ranging from 8.3-14.5 g/dl. Mean hemoglobin level of normal non-diabetic controls was 12.5+1.86 g/dl with range of 10.1-17.1 g/dl (p-value>0.005). The mean corpuscular volume of red blood cells of β-thalassemia traits was 61.74+7.25fl. The range of mean corpuscular volume among β-thalassemia traits was 52.2-93.9fl.Mean corpuscular volume of controls was 74.4+7.6 fl ranging from 61.1 to 92.6 fl (p-value >0.005). Red cell distribution width among cases and controls was 40.54 +4.27 fl and 42.38+4.24 fl. The range of red cell distribution width among cases and controls was 32.7-57.9 and 30.5-53.7 fl (p-value >0.005). The mean red cell count of β-thalassemia traits was 6.23+ 0.80*106/million with a range of 4.5-8*106/million.Mean red cell count of cases and was 5.14+0.80*106/million ranging from 3-6.5*106/million (p-value>0.005). The mean value of glycosylated hemoglobin A1C in non-diabetics i.e controls and β-thalassemia traits i.e cases was 5% and 5.04% (p-value>0.005) i.e mean level of glycosylated hemoglobin A1C were comparable in both cases and controls.
Conclusion: Hemoglobin A1C can be used to monitor glycemic control in β-thalassemia traits.
Keywords: β-thalassemia traits; Glycosylated hemoglobin A1C High-performance liquid chromatography
Citation: Shakoor HA, Raza M, Amanat ST, Syed S, Ali S, et al. (2022) Comparison of Mean Level of Hemoglobin A1C Between β-thalassemia Traits and Normal Non- Diabetic Individuals. J Clin Exp Pathol 12: 406. Doi: 10.4172/2161-0681.1000406
Copyright: © 2022 Shakoor HA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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