ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Research Article   
  • J Infect Dis Ther,

Comparing the Outcomes Associated with Three Treatment Durations of Pseudomonas and Acinetobacter Bloodstream Infection

Jamal Wadi Al Ramahi1*, Ayad Abdullah Al-Qadasi2, Sewar Saed Fraij3, Ahmad Bassam Alayyat4, Asma’a Rezeq Tanash3, Nour Mohammad Hasan5, Amal Matar5, Renad Mohammad Khader6, Asaiel Zaid Makahleh6, Ibraheem Zuhair A.R. Mohialdeen6, Haya Moh’d Hamarsha6, Zaid Antwan Tewfiq Al Khouri6, Zaid Ali Zuhair Elkarmi6, Lara Abdulhadi5 and Farah A. Abdallah7
1Department of Medicine, The University of Jordan, Amman, Jordan
2Department of Medicine, The Specialty Hospital, Amman, Jordan
3Pharmacy Department, The Specialty Hospital, Amman, Jordan
4Department of Medicine, Al Khalidi Hospital and Medical Center, Amman, Jordan
5Pharmacy Department, Al Khalidi Hospital and Medical Center, Amman, Jordan
6Department of Medicine, Jordan Hospital, Amman, Jordan
7Department of Research, King Hussein Cancer Center, Amman, Jordan
*Corresponding Author : Jamal Wadi Al Ramahi, Department of Medicine, The University of Jordan, Amman, Jordan, Email: jamalwadimd@yahoo.com

Received Date: Jul 22, 2022 / Published Date: Aug 23, 2022

Abstract

Background: The proper duration for treating patients with non-fermenting gram-negative bacteremia is not yet defined; we attempt to find an appropriate course of treatment.

Methods: A retrospective multicenter study in three hospitals, Amman-Jordan. Medical records were reviewed for patients with Lactose Non-Fermenting Gram-Negative (LNF) bacteremia. Information on blood cultures was extracted from the microbiology logbook and records. For adults >18 years, primary bacteremia and a known source were included. Patients who needed prolonged antibiotics treatment due to the nature of their infections; neutropenic cancer patients, organs with abscesses/empyema, CVC retention, polymicrobial septicemia, and expected survival ≤ 48 hours. Continuous variables were analyzed by (χ2), Mann-Whitney test, ANOVA for means, and the Bonferroni for pairwise comparisons for P-value <0.05. SPSS version-25 was used in the analysis.

Results: Included patients were 115 with LNF gram-negative growth on blood cultures, distributed as follows: patients with one-week treatment duration were 45, two-week 43, and three-week duration was 27. Characteristics were balanced (P>0.05) except for chronic lung disease, and a few antibiotics were more in the three-week duration (P<0.05). There was a significant difference for 28-day all-cause mortality (P=0.019), but relapse and reinfection did not significantly differ among the three treatment durations (P>0.05). The relapse rate was 3%, and a new infection was 7%.

Conclusion: There was no significant difference for one-week, two-week, and three-week antibiotics treatment durations in the 90- day all-cause mortality, relapse, and reinfection rates, but increased 28-day mortality in the three-week duration.

Keywords: Bloodstream infection; Acinetobacter relapse; Mortality; Antimicrobial therapy

Citation: Al Ramahi JW, Al-Qadasi AA, Fraij SS, Alayyat AB, Tanash AR, et al. (2022) Comparing the Outcomes Associated with Three Treatment Durations of Pseudomonas and Acinetobacter Bloodstream Infection. J Infect Dis Ther S5:004.

Copyright: © 2022 Al Ramahi JW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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