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Hindi Comparative Dissolution and Disintegration Study of Different Brands of Linezolid 600 mg Tablets Available in Karachi, Pakistan
Abstract
The dissolution and disintegration tests (USP) are extensively useful for the determination of the safe and effective drugs as well as used for the stability and quality of the drug product. The purpose of the study was to observe the disintegration and dissolution profile (UV spectrophotometer), and estimation of the quality through weight variation and hardness test of different brands of Linezolid 600 mg tablets from Karachi, Pakistan. The weight variation test for all the brands was found to be under normal limits and the hardness of all the brands was also within normal limits. The tablet disintegration time was as per the specifications and all the tablets were disintegrated within 30 minutes except for brand C3, which disintegrates within 3.98 minutes and provided better disintegration time. Although, all the brands showed better dissolution rate, but the percent drug release of C1 was found to be the best, i.e. 100% drug was dissolved in 30 minutes in contrast to the different brands. Dissolution test is comparatively an efficient and cost effective in vitro approach that can be helpful in the assessment of the release attributes of formulation. It was found that brand C1 and C2 exhibited better dissolution profile as compared to other brands. Although, C3 and C4 were also found to be under the limits i.e. 80 % of the label amount of the drug.
