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Comparative Analysis of Nasal Therapy with Soluble and Liposomal Forms of Curcumin on Rats with Alzheimer’s Disease Model
Sokolik VV1, Berchenko OG1 and Shulga SM2*1Laboratory of Neurophysiology, Immunology and Biochemistry SE, Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Science of Ukraine, Kharkiv, Ukraine
2Department of Industrial and Food Biotechnology SE, Institute for Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
- Corresponding Author:
- Shulga SM
Department of Industrial and Food Biotechnology SE
Institute for Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tel: +38067 4400531
E-mail: shulga5@i.ua
Received date: May 04, 2017; Accepted date: July 25, 2017; Published date: August 01, 2017
Citation: Sokolik VV, Berchenko OG, Shulga SM (2017) Comparative Analysis of Nasal Therapy with Soluble and Liposomal Forms of Curcumin on Rats with Alzheimer’s Disease Model. J Alzheimers Dis Parkinsonism 7:357. doi:10.4172/2161-0460.1000357
Copyright: © 2017 Sokolik VV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The aim of this study was a comparative analysis of the efficacy of nasal therapy of curcumin soluble and liposomal forms of animals with a model of Alzheimer’s disease. Cognitive tests and immunity-enzyme analysis of cytokines were completed. On experimental model of Alzheimer’s disease in rats (intrahippocampus administration of 15 nÃÂÃÅ ÃÂÃÂβ42_Human) installed more efficient nasal therapy (1 month treatment) of curcumin liposome form (3.5 μg/animal daily) has turned out more efficient compared to its aqueous solution, both in terms of cognitive tests (the portion of the positive responses and latent period of the conditioned reflex reaction elimination) and in neuroinflammation (cytokines content (interleukin-1β, interleukin-6, interleukin-10, tumor necrosis factor α) in the brain sections: cerebral cortex and hippocampus of the rats with Alzheimer’s disease model). The data indicate a high anticytokine potential specifically of the liposomal form of curcumin.
