Clozapine induces metformin-resistant prediabetes/diabetes that's related to poor clinical efficaciousness in patients with early treatment-resistant schizophrenic disorder
Received Date: Jun 29, 2022 / Published Date: Jul 29, 2022
Abstract
Two distinct subtypes of treatment-resistant dementia praecox (TRS) are recently rumored, as well as earlytreatment resistance (E-TR) and late-treatment resistance (L-TR). This study was to assess clozapine-induced metformin-resistant prediabetes/diabetes and its correlation with clinical effectiveness in dementia praecox E-TR subtype. The incidence of clozapine-induced metformin-resistant prediabetes/diabetes was significantly high in dementia praecox early-treatment resistance (E-TR) subtype. Clozapine-induced metformin-resistantprediabetes/diabetes depicted associate degree freelance risk issue that adversely affected the clinical effectiveness of neuroleptic agent for dementia praecox E-TR subtype. Switching to neuroleptic agent strategy ought to be reconsidered within the treatment of patients with dementia praecox E-TR subtype. Given the high incidence of metformin-resistant clozapine-induced prediabetes/diabetes, the viability of manner interventions to stop clozapineinduced prediabetes/diabetes in patients with dementia praecox E-TR subtype ought to be assessed in future studies.
Citation: Shao H (2022) Clozapine Induces Metformin-Resistant Prediabetes/ Diabetes that’s Related to Poor Clinical Efficaciousness in Patients with Early Treatment-Resistant Schizophrenic Disorder. J Clin Diabetes 6: 145. Doi: 10.4172/jcds.1000145
Copyright: © 2022 Shao H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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