Clinical Findings Showing that Non-Convulsive Electric Shock Administration for Patients Receiving Clozapine Therapy for Schizophrenia May Contribute to Stability of Granulocyte Number, the Most Critical Drug Side-Effect
Received Date: Jan 09, 2017 / Accepted Date: Feb 11, 2017 / Published Date: Feb 20, 2017
Abstract
Two treatment-resistant schizophrenic patients were administered clozapine, but showed a decrease in granulocytes. As an alternative treatment, we administered non-convulsive Electric Shock Therapy (ECT) (modified- ECT: m-ECT) to both and the number of granulocytes increased to a level considered safe for clozapine ingestion. Then, under continuation of m-ECT, we gradually increased the dose of the drug. After 10-14 m-ECT sessions in both patients, the number of granulocytes became stable at approximately 5000/mm3 and m-ECT was completed. Our findings show the possibility of treatment for therapy-resistant patients who are unable to receive clozapine because of reduced granulocyte number.
Keywords: Clozapine therapy; Electric shock; Schizophrenia; Granulocytes
Citation: Sugita K, Mori Y, Kanemoto K, Sugita S (2017) Clinical Findings Showing That Non-Convulsive Electric Shock Administration for Patients Receiving Clozapine Therapy for Schizophrenia May Contribute to Stability of Granulocyte Number, the Most Critical Drug Side-Effect. J Neuropsychopharmacol Mental Health 2: 115.
Copyright: © 2017 Sugita K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any Smedium, provided the original author and source are credited.
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