Abstract

Palliative medicine aims to enhance the quality of life for patients with serious illnesses by managing complex symptoms such as pain, nausea, cognitive impairment, and sleep disturbances. Histamine H3 receptors, primarily located in the central nervous system, regulate the release of multiple neurotransmitters involved in these physiological processes. H3 receptor modulators, including antagonists and inverse agonists, have shown significant potential in addressing the multifaceted needs of palliative care patients. This article explores the clinical applications of H3 receptor modulators in palliative medicine, highlighting their role in pain management, cognitive function enhancement, nausea control, and sleep improvement. It also discusses the integration of these modulators into personalized, multidisciplinary treatment plans, emphasizing the need for comprehensive symptom assessment, patient and caregiver education, and ongoing research to establish their efficacy and safety. By leveraging the benefits of H3 receptor modulation, palliative care can achieve more effective symptom relief and improved patient outcomes.