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Hindi Chronic Lyme Disease: Why Is This Still Controversial?
*Corresponding Author: Daniel A Kinderlehrer, Private Practice, 668 South Newport St, Denver Colorado, USA, Email: kinderlehrer@gmail.comReceived Date: Mar 26, 2024 / Published Date: Apr 25, 2024
Citation: Kinderlehrer DA (2024) Chronic Lyme Disease: Why Is This Still Controversial? J Infect Dis Ther 12:586.DOI: 10.4172/2332-0877.1000586
Copyright: © 2024 Kinderlehrer DA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
While it is clear that a cohort of patients treated for acute Lyme disease continue to have persistent symptoms, the etiology of these symptoms remains controversial despite clear evidence that multiple mechanisms may be responsible for their etiopathogenesis. These include persistent infection with Borrelia burgdorferi; the existence of coinfections; chronic systemic inflammation associated with dysregulation of the immune system, autoimmunity, and excessive mast cell activation; and dysregulation of the autonomic nervous system. Rather than rely on flawed IDSA guidelines, it is incumbent on physicians to seriously investigate the underlying mechanisms of chronic symptoms in these patients.
