Abstract

Relevance: The elucidation of molecular mechanisms of cardiac activity is an important issue. The search for new means of pathogenic correction of cardiovascular system activity disorders at myocardial infarction of various genesis, angina pectoris based on atherosclerotic process is still actual.

Objective: To determine the main intermediates in arterial and venous blood in norm, acute and sub-acute phase of myocardial infarction and during scarring.

Materials and Methods: Experiments were carried out in two series with a total of 46 experimental animals. The hearts of 5 experimental and 5 control animals were used in in vitro experiments. In vivo experiments on exogenous enzyme injection were performed on 12 experimental and 7 control animals.

Results: Clearly increased molar concentration of compounds with marked acidic properties creates the preconditions of metabolic acidosis. Fluctuations of the total serum protein at the lower limit of the norm cause the possibility of its development.

Conclusion: The presence of correlation between metabolic shifts in the heart muscle and in peripheral blood, aortic blood in the dynamics of myocardial infarction provides the possibility to use determination of free fatty acids, dioxyacetone phosphate, and oxaloacetate content as diagnostic tests.