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Cerebral Vasoreactivity in Parkinson's Disease: A Cross-Sectional Pilot Study in a Hispanic Cohort
Alba Espino Ojeda1, Héctor R Martinez1,3*, Fernando Góngora Rivera1,3, Juan M Escamilla Garza3, Héctor Canfield Medina2 and Sergio Saldívar Dávila31Neurology and Neurosurgery Institute, Zambrano-Hellion Medical Center, Tecnológico de Monterrey, San Pedro Garza García N.L., Mexico
2National School of Medicine of the Tecnológico de Monterrey, Monterrey N.L., México
3Neurology Service University Hospital UANL, Monterrey N.L., Mexico
- Corresponding Author:
- Héctor R Martinez
San Patricio Battalion 112 Central 8th floor. Col. Real de San Agustín C.P 66278
San Pedro Garza García, N.L. Mexico
Tel: 518181623412
E-mail: dr.hectormartinez@tecsalud.mx
Received date: May 29, 2017; Accepted date: June 13, 2017; Published date: June 20, 2017
Citation: Ojeda AE, Martinez HR, Rivera FG, Garza JME, Medina HC, et al. (2017) Cerebral Vasoreactivity in Parkinson’s Disease: A Cross-Sectional Pilot Study in a Hispanic Cohort. J Alzheimers Dis Parkinsonism 7:336. doi:10.4172/2161-0460.1000336
Copyright: © 2017 Ojeda AE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: Abnormalities in cerebral vasomotor reactivity (CVR) in patients with idiopathic Parkinson’s disease (IPD) have not been well determined; nonetheless, a vascular mechanism may be involved in some patients with this neurodegenerative disorder. The objective of this study was to compare CVR in IPD patients and subjects without Parkinson’s disease. Methods: A cross-sectional pilot study was conducted including Hispanic IPD patients and a control group. CVR in the middle cerebral arteries (MCA) was measured by transcranial Doppler ultrasonography (TCD) at rest and after inhalation of 7% CO2. A comparison of CVR in the MCA of both groups was performed. Results: 27 IPD Hispanic patients with a recent brain MRI were evaluated. The CVR showed a significant difference between the two groups (p=0.044). The CVR in 70% of the IPD patients was low in comparison to control subjects. Conclusion: IPD patients are prone to exhibit diminished CVR in comparison with control group. Further studies may demonstrate this tendency and its implication in disease severity.
