Journal of Infectious Diseases & Therapy
Open Access

Research Article

Central Venous Oxygen Saturation above 75% on Day Three of Septic Shock is Associated with Tripled Mortality

Timo Sturm^1,2*, Jan Dertinger^1,2, Michael Hagmann^1,2, Manfred Thiel^1,2 and Verena Schneider-Lindner^1,2,3

¹University Medical Centre Mannheim, Department of Anaesthesiology and Surgical Intensive Care Medicine, Mannheim, Germany

²TRACC-Group (Translational Research in Anaesthesiology and Critical Care), Canada

³Department of Community Health Sciences, University of Manitoba, Winnipeg, Canada

*Corresponding Author:

Timo Sturm
University Medical Centre Mannheim
Department of Anaesthesiology and Surgical Intensive Care Medicine
Theodor-Kutzer-Ufer 1-3 68167, Mannheim, Germany
Tel: 0049-6213832415
E-mail: timo.sturm@med.uni-heidelberg.de

Received date: September 26, 2017; Accepted date: October 10, 2017; Published date: October 12, 2017

Citation: Sturm T, Dertinger J, Hagmann M, Thiel M, Schneider-Lindner V (2017) Central Venous Oxygen Saturation above 75% on Day Three of Septic Shock is Associated with Tripled Mortality. J Infect Dis Ther 5:338. doi: 10.4172/2332-0877.1000338

Copyright: © 2017 Sturm T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Background: Central venous oxygen saturation (ScvO₂) is commonly used to identify global oxygen uptakedelivery mismatches. A level above 70% was the declared goal in early resuscitation of septic shock for over a decade. Recent evidence leads to doubts and levels higher than 80% may represent harmful conditions. This study ´s aim was to identify favourable ScvO₂ levels in treatment of septic shock.

Methods: Electronic data of patients suffering from septic shock who have been admitted to the surgical intensive care unit of a university hospital were analysed surveying a period of six years with focus on the association of ScvO₂ levels with in-hospital mortality.

Results: Data from 238 individuals were included. No difference was found comparing initially measured values of ScvO₂ of survivors to non-survivors. Patients whose levels of ScvO₂ never exceeded 70% (n=28) had a higher mortality rate (73.2% vs. 54.3%, p<0.05). On day three patients with values above 75% (n=32) had higher mortality rates (59.4% vs. 38.5%, p<0.05). A mortality rate of 100% was detected if ScvO₂ levels exceeded 84% (n=6).

Conclusions: ScvO₂ develops from a therapy guiding parameter to a prognostic marker. Reaching levels of at least 70% within the first 72 h of disease is favourable in regard to prognosis. Exceeding 75% after day two is associated with higher mortality. These findings require further confirmation. At this point it can be assumed that a varying, time-dependent ScvO₂ approach might be required for clinical decision-making.

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