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Hindi Cellular uptake and cytotoxicity studies of pH-responsive polymeric Nano particles fabricated by dispersion polymerization
*Corresponding Author:
Copyright: © 2019 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Puri R, Adesina S, Akala E. Cellular uptake and cytotoxicity studies of pH-responsive polymeric Nano particles fabricated by dispersion polymerization. A strategy in site-specific drug delivery is the use of pHgradients that exist in diseased conditions such as cancer for the release of loaded drug(s) in the biophase. The objective of this work is to synthesize pH-responsive docetaxel-loaded Nano particles with a bisacrylate acetal crosslinker, which can get internalized into cells, and which will be equivalent to or more cytotoxic than the free drug against cancer cells.
