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Hindi Research Article
CD4+T Cells Expansion in P. berghei (NK-65) Infected and Immunized BALB/C Mice
Vineet Kumar1, Aruna Rakha2, Ruchika Saroa1 and Upma Bagai1*1Parasitology Laboratory, Department of Zoology, Panjab University, Chandigarh160014, India
2Department of Translational and Regenerative Medicine, PGIMER, Chandigarh 160012, India
- *Corresponding Author:
- Bagai U
Associate Professor
Department of Zoology
Panjab University
Chandigarh-160014, India
Tel: 919876669632
E-mail: upmabagai@yahoo.co.in
Received Date: March 30, 2015; Accepted Date: May 21, 2015; Published Date: May 25, 2015
Citation: Kumar V, Rakha A, Saroa R, Bagai U (2015) CD4+T Cells Expansion in P. berghei (NK-65) Infected and Immunized BALB/C Mice. J Clin Exp Pathol 5:229. doi:10.4172/2161-0681.1000229
Copyright: ©2015, Vineet Kumar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The immune system of malaria infected host undergoes both activation and suppression during different phases of parasite’s life cycle. In Plasmodium chabaudi chabaudi (AS), T helper cells of host have been reported to be necessary for inducing a protective immune response against the blood stages of parasite [1]. T cells provide protection to infection by cytokine-mediated mechanisms or through production of antibodies. Experiments with B cell deficient mice have demonstrated that B cells and antibodies are essential for complete clearance of parasites from blood of the host [2]. Depending upon the cytokines secreted by the Helper T cells, they are classified into two subpopulations: Th1 and Th2 cells. Th1 cells primarily release IFN-γ, IL-2, whereas, Th2 cells secrete IL-4, IL-5, IL-6, IL-10 and IL-13.
