Abstract

Peripheral neuropathy is a rare but recognized complication associated with certain medications, including isoniazid (INH) used in tuberculosis (TB) treatment. We present the case of a 56-year-old male with a history of pulmonary TB treated with a regimen including INH, who developed progressive tingling and numbness in his feet and hands. Clinical examination and nerve conduction studies confirmed a diagnosis of isoniazid-induced peripheral neuropathy. Prompt cessation of INH and modification of TB therapy led to symptomatic improvement and stabilization of neuropathy. This case underscores the importance of considering medication-related neuropathies in patients on anti-TB regimens and the need for early recognition and management to prevent further neurological complications.