Abstract

Cardiac toxicity represents a significant concern in both clinical practice and drug development. This article provides a comprehensive overview of cardiac toxicity, focusing on its mechanisms, risk factors, and management strategies. Cardiotoxicity can result from various factors, including chemotherapy agents, environmental toxins, and certain medications. Understanding the underlying mechanisms, such as oxidative stress, mitochondrial dysfunction, and inflammation, is crucial for developing effective prevention and treatment strategies. Additionally, identifying patient- specific risk factors, such as pre-existing cardiovascular disease and genetic susceptibility, can help personalize management approaches. Management strategies for cardiac toxicity encompass a multidisciplinary approach, including close monitoring, early detection, dose modification, and supportive care. Furthermore, emerging therapeutic interventions, such as cardio-protective agents and targeted therapies, hold promise in mitigating cardiac toxicity and improving patient outcomes. Overall, this article highlights the importance of recognizing and managing cardiac toxicity to optimize patient care and enhance drug safety profiles.