Abstract

Mast cells, traditionally known for their role in allergic responses, are increasingly recognized for their involvement in immune modulation and host defense beyond allergic reactions. This review explores the emerging understanding of brain mast cells (BMCs) and their potential therapeutic applications in combating bacterial and viral infections. BMCs, located in the central nervous system (CNS), possess unique immunological properties that influence neuroinflammation and host defense mechanisms. Recent studies indicate BMCs' ability to respond to pathogens directly and modulate immune responses in infectious diseases. Understanding BMCs' capabilities and harnessing their therapeutic potential could lead to novel strategies for treating infections affecting the CNS and beyond.