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Can too Much Antibiotic Prophylaxis in Arthroplasty Surgery be Harmful? Results of a Series of Cases Study
| José María Barbero*, Eduardo Montero, Rosa Agudo, Marta García, Ángela Rebollar, Luis Gete, Ana Culebras and Joaquín López | ||
| Department of Internal Medicine, Division of Medical Support to Surgeries Departments, Príncipe de Asturias Universitary Hospital, Alcalá de Henares, Madrid, Spain | ||
| Corresponding Author : | José María Barbero Allende Alcala-Meco Road, Príncipe de Asturias Universitary Hospital Alcalá de Henares, 28805, Madrid, Spain Tel: 034918878100 E-mail: j:_m_barbero@yahoo.es |
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| Received August 28, 2014; Accepted October 22, 2014; Published October 29, 2014 | ||
| Citation: Barbero JM, Montero E, Agudo R, García M, Rebollar A, et al. (2014) Can too Much Antibiotic Prophylaxis in Arthroplasty Surgery be Harmful? Results of a Series of Cases Study. J Infect Dis Ther 2:177. doi:10.4172/2332-0877.1000177 | ||
| Copyright: © 2014 Barbero JM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ||
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Abstract
Background: Preoperative antibiotic prophylaxis has been shown to decrease the incidence of surgical wound infection. Prosthetic joint infection (PJI) is a type of surgical wound infection with serious consequences.
Objective: The purpose of this study is to evaluate whether expanding the antibiotic prophylaxis with repeated doses in the postoperative period may lead to an increase in the incidence of PJI.
Patients and methods: We retrospectively analyzed 556 patients undergoing hip or knee primary arthroplasty in our hospital between January 1, 2009 and December 31, 2010. All the patients received a preoperative dose of an antibiotic and 164 patients also received at least one additional dose after surgery.
Results: There were 16 PJI (incidence of 2.9%). PJI occurred in 7/94 patients with repeated doses of antibiotics after surgery (7.4%), compared to 9/462 (1.9%) in patients who only received the preoperative dose (odds ratio [OR] 3.1, confidence interval [CI] 95% 1.1 to 9.4, p=0.04).
Conclusions: In our study, the patients who received antibiotics after surgery were at greater risk of developing PJI.
